凝固
1999-01-01 00:00 by kcrt
凝固因子
| CLOTTING FACTOR | SYNONYM | DISORDER |
|---|---|---|
| I | Fibrinogen | Congenital deficiency (afibrinogenemia) or dysfunction (dysfibrinogenemia) |
| II | Prothrombin | Congenital deficiency or dysfunction |
| V | Labile factor, proaccelerin | Congenital deficiency (parahemophilia) |
| VII | Stable factor or proconvertin | Congenital deficiency |
| VIII | Antihemophilic factor | Congenital deficiency is hemophilia A (classic hemophilia) |
| IX | Christmas factor | Congenital deficiency is hemophilia B |
| X | Stuart-Prower factor | Congenital deficiency |
| XI | Plasma thromboplastin antecedent | Congenital deficiency, sometimes referred to as hemophilia C |
| XII | Hageman factor | Congenital deficiency is not associated with clinical symptoms |
| XIII | Fibrin-stabilizing factor | Congenital deficiency |
凝固基準値 (Nelson 8th ed.)
| TEST | 28-31 WK GESTATION | 30-36 WK GESTATION | FULL TERM | 1-5 YR | 6-10 YR | 11-18 YR | ADULT |
|---|---|---|---|---|---|---|---|
| SCREENING TESTS | |||||||
| Prothrombin time (PT) (sec) | 15.4 (14.6-16.9) | 13.0 (10.6-16.2) | 13.0 (10.1-15.9) | 11 (10.6-11.4) | 11.1 (10.1-12.0) | 11.2 (10.2-12.0) | 12 (11.0-14.0) |
| Activated partial thromboplastin time (APTT) (sec) | 108 (80-168) | 53.6 [27.5-79.4]‡ | 42.9 31.3-54.3 | 30 (24-36) | 31 (26-36) | 32 (26-37) | 33 (27-40) |
| Bleeding time (BT) (min) | 6 2.5-10 | 7 2.5-13 | 5 3-8 | 4 (1-7) | |||
| PROCOAGULANTS | |||||||
| Fibrinogen | 256 (160-550) | 243 [150-373]‡ | 283 (167-399) | 276 (170-405) | 279 (157-400) | 300 (154-448) | 278 (156-40) |
| Factor II | 31 (19-54) | 45 20-77 | 48 26-70 | 94 71-116 | 88 67-107 | 83 61-104 | 108 (70-146) |
| Factor V | 65 (43-80) | 88 41-144 | 72 34-108 | 103 (79-127) | 90 63-116 | 77 55-99 | 106 (62-150) |
| Factor VII | 37 (24-76) | 67 21-113 | 66 28-104 | 82 55-116 | 86 52-120 | 83 58-115 | 105 (67-143) |
| Factor VIII procoagulant | 79 (37-126) | 111 (5-213) | 100 (50-178) | 90 (59-142) | 95 (58-132) | 92 (53-131) | 99 (50-149) |
| von Willebrand factor (VWF) | 141 (83-223) | 136 (78-210) | 153 (50-287) | 82 (60-120) | 95 (44-144) | 100 (46-153) | 92 (50-158) |
| Factor IX | 18 (17-20) | 35 [19-65]‡ | 53 [15-91]† | 73 47-104 | 75 63-89 | 82 59-122 | 109 (55-163) |
| Factor X | 36 (25-64) | 41 11-71 | 40 12-68 | 88 58-116 | 75 55-101 | 79 (50-117) | 106 (70-152) |
| Factor XI | 23 (11-33) | 30 [8-52]‡ | 38 40-66 | 30 8-52 | 38 (10-66) | 74 50-97 | 97 (56-150) |
| Factor XII | 25 (5-35) | 38 [10-66]‡ | 53 13-93 | 93 (64-129) | 92 (60-140) | 81 34-137 | 108 (52-164) |
| Prekallikrein (PK) | 26 (15-32) | 33 9-89 | 37 18-69 | 95 (65-130) | 99 (66-131) | 99 (53-145) | 112 (62-162) |
| High molecular weight kininogen (HMWK) | 32 (19-52) | 49 9-89 | 54 6-102 | 98 (64-132) | 93 (60-130) | 91 (63-119) | 92 (50-136) |
| Factor XIIIa[¶] | 70 32-108 | 79 27-131 | 108 (72-143) | 109 (65-151) | 99 (57-140) | 105 (55-155) | |
| Factor XIIIb[¶] | 81 35-127 | 76 30-122 | 113 69-156 | 116 77-154 | 102 (60-143) | 98 (57-137) | |
| ANTICOAGULANTS | |||||||
| Antithrombin-III (AT-III) | 28 (20-38) | 38 [14-62]‡ | 63 39-87 | 111 (82-139) | 111 (90-131) | 106 (77-132) | 100 (74-126) |
| Protein C | 28 [12-44]‡ | 35 17-53 | 66 40-92 | 69 45-93 | 83 55-111 | 96 (64-128) | |
| Protein S: | |||||||
| Total (U/mL) | 26 [14-38]‡ | 36 12-60 | 86 (54-118) | 78 (41-114) | 72 (52-92) | 81 (61-113) | |
| Free (U/mL) | 45 (21-69) | 42 (22-62) | 38 (26-55) | 45 (27-61) | |||
| Plasminogen (U/mL) | 170 112-248 | 195 125-265 | 98 (78-118) | 92 (75-108) | 86 (68-103) | 99 (77-122) | |
| Tissue type plasminogen activator (TPA) (ng/mL) | 8.48 (3.00-16.70) | 9.6 (5.0-18.9) | 2.15 1.0-4.5 | 2.42 1.0-5.0 | 2.16 1.0-4.0 | 1.02 (0.68-1.36) | |
| Antiplasmin (α2AP) (U/mL) | 78 (40-116) | 85 (55-115) | 105 (93-117) | 99 (89-110) | 98 (78-118) | 102 (68-136) | |
| Plasminogen activator inhibitor-I (PAI-1) | 5.4 0.0-12.2 | 6.4 (2.0-15.1) | 5.42 (1.0-10.0) | 6.79 2.0-12.0 | 6.07 2.0-10.0 | 3.60 (0.0-11.0) |
- All factors except fibrinogen are expressed as units/mL (fibrinogen in mg/mL), in which pooled normal plasma contains 1 U/mL. All data are expressed as the mean, followed by the upper and lower boundaries encompassing 95% of the normal population (shown in parentheses). † Levels for 19-27 wk and 28-31 wk gestation are from multiple sources and cannot be analyzed statistically. ‡ Values are significantly different from those of adults. § Values are significantly different from those of full-term infants. ¶ Value given as CTA (Committee on Thrombolytic Agents) units/mL.